alpha keto glutarate
alpha keto glutaric acid
This substance in the citric acid cycle gets the most versatile action. It can cycle
within the citrate cycle, as shown, or shunt off by becoming glutamine.
CO OH Glutamine
Glutamine is a neurotransmitter. It is a precursor of Creatine Phosphate, a key
energy shuttle in skeletal muscle. It is a precursor of Ornithine an important urea cycle component also leading to arginine and proline (important amino acids) and
the polyamines. It is a precursor of the neurotransmitter gama-amino-butyric acid an important chemical in spasticity. It is a precursor of glutathione and folate polyglutamates. Glutamine is used as a direct neurotransmitter in the brain. In
short, this is a very important link in the citric acid cycle.
To the degree that each substance is tied to glutaric acid is the degree to which mitochondria are important in that segment of metabolism.